Paola is a 3-year-old girl with a disease that reduces the ability of her mitochondria to generate ATP. Explain the specific effects of this disease on the ability of Paola's muscles to function properly. What other tissues and organs are likely to be especially affected by her disease, and why?
Some athletes will consume only protein for several days before a competition, which reduces the amount of glycogen in both the muscle fibers and the liver. What effect would this have on their ability to perform activities that require short, powerful bursts of activity? How would it affect their ability to perform endurance activities?
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Key Concepts
Glycogen Storage
Energy Systems
Performance Implications
Mr. Nasheed has cerebral palsy and suffers severe skeletal muscle spasms as a result of his condition. He is prescribed the drug dantrolene, which prevents the release of Ca2+ from the SR. Explain how this will treat his muscle spasms.
The primary action of the biceps brachii muscle of the anterior arm is to flex the forearm at the elbow. However, when this muscle is inflamed, pain is felt in the shoulder. Explain this finding.
Match the following terms with the correct definition.
____Z-disc
____Sarcomere
____A band
____H zone
____I band
____M line
a. The dark band containing the entire length of the thick filament
b. The band of proteins in the middle of the H zone
c. The boundary between sarcomeres
d. The functional unit of contraction
e. The middle region of the A band containing only thick filaments
f. The light band containing only thin filaments
Jesse is a 2-year-old boy who presents with difficulty in walking and poor control of movements. When the doctor examines Jesse, she notices that when his muscles contract, they are very slow to relax and remain contracted well after the movement has been performed. She sends a sample of his tissue for genetic analysis, and the lab reports a genetic defect that causes the pumps in the SR to operate much more slowly than normal. How does a defect in DNA lead to a malfunctioning protein? How does this finding explain Jesse's symptoms?
Ms. Sanchez was in a motorcycle accident in which she lost the use of her right upper limb muscles due to significant nerve damage. However, when an electrode is inserted into her muscles, they are able to contract. Explain specifically why nerve damage caused her to lose the use of her muscles. Why can they still respond to stimulation from an electrode?
