The drug methotrexate is used to treat several different types of cancer and diseases of the immune system. It works by inhibiting an enzyme in the cell necessary for folic acid synthesis. Without folic acid, the cell cannot make nucleotides. What, specifically, does an enzyme do in the cell? Why would inhibiting this enzyme disrupt folic acid synthesis? What effect would a disruption in folic acid synthesis have on the cell as a whole? (Hint: Think about the role that folic acid plays in the cell.) (Connects to Chapter 2)
Which of the following statements correctly describes a solution?
a. In a solution the solute is chemically dissolved by the solvent.
b. Solutions involve large particles suspended in another component.
c. The particles in a solution will settle out if left to sit.
d. The amount of solute in a solution is expressed as the solution's concentration.
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Key Concepts
Solution Definition
Concentration
Suspension vs. Solution
Considering that water is a main component of the juices in the stomach and intestines, explain why digestion of lipids is more complicated than digestion of carbohydrates and proteins.
In certain types of radioactive decay, the isotope releases a particle called an alpha particle, which contains two protons and two neutrons. When this happens, is the product still the same element? Why or why not?
Many drugs and poisons exert their effects by blocking one or more enzymes. How could blocking an enzyme lead to the death of a cell?
The polysaccharide cellulose is not digestible by humans, as we lack the enzyme cellulase, which is required to break it down. Certain dietary supplements contain the enzyme cellulase and claim that being able to break down cellulose will help a person lose weight. But what do you think would happen if we could digest the cellulose we ate?
