Fouz Akkad is a 6-year-old girl who has been diagnosed with a rare genetic defect in which her lysosomes are unable to maintain an acidic pH. What are lysosomes? Why do lysosomes require an acidic pH? How will this affect the ability of certain bone cells to function? What consequences will this disease have on Fouz's bones?
Explain the differences between red bone marrow and yellow bone marrow.
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Key Concepts
Red Bone Marrow
Yellow Bone Marrow
Hematopoiesis
How could a disease that affects primarily cartilage impact bone growth and bone formation?
How could diseases of the kidney, skin, and/or intestines cause diseases of the bone?
Explain why young men who take anabolic steroids (which mimic the actions of testosterone) often display stunted growth and have an overall shorter stature.
Explain why a person who is wheelchair-bound or bed-bound often has very low bone mass, especially in his or her legs.
Lucy Dupre is a 2-year-old girl living in northern Canada. You notice that her growth seems abnormally slow and she has exhibited signs of weakened bones, including fractures. Her parents admit they have not supplemented her diet with vitamin D, as they feel that any supplementation is 'unnatural' and 'not organic.' Explain why Lucy is having problems with her bones and bone growth.
