Pyruvate Oxidation - Video Tutorials & Practice Problems
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Pyruvate Oxidation Concept 1
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Hey, everyone. So when it comes to the Pyruvate oxidation, recall that one glucose is converted into two pyruvate molecules through the glycolysis pathway. Remember this pathway here is linear in nature and we're gonna say the fate of the pyruvate depends on the availability of oxygen in the cells. So if we take a look here at the steps or stages of food metabolism, and we're paying attention to the monosaccharide. In this case, we'll talk about amino acids and fatty acids in later sections. But for now, we have our monosaccharide that go into the cytosol and this is where glycolysis takes place. Now, remember glycolysis here will create an A DH as an energetic molecule as well as a TP. In addition to this, um we're going to make our pyruvate molecule within stage two, that pyruvate could take one of two directions. If there is no oxygen available, then it would go towards fermentation where we have anaerobic respiration. We'll talk about that later on. Now, if oxygen is present, then it continues forward into the acetyl coa formation. This then takes us into the mitochondrial matrix where we're dealing with stages three, which deals with the crept cycle or citric acid cycle. And then from there into stage four where we're dealing with the etc and oxidative phosphorylation for the generation of A TP molecules. So just remember this section here is called our common metabolic pathway. And it's in this portion where oxygen is available. And so we're dealing with aerobic respiration. So just remember, pyruvate can do one of two things based on the availability of oxygen.
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Pyruvate Oxidation Concept 2
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Now remember the fate of pyruvate is based on the availability of oxygen. Now, when oxygen is available, we undergo aerobic respiration. Here, we're gonna say in the presence of oxygen. So 0002, we're gonna say pyruvate is transported from cytosol to the mitochondrial matrix. Here, we're going to say that pyruvate is oxidized by pyruvic dehydrogenase to acetyl coa. Now remember when it comes to our oxidation reactions, a class of enzymes that we're going to utilize are the dehydrogenase. That's why it's pyruvate dehydrogenase. It's the substrate name followed by dehydrogenase. Now, here in this process, one N ad positive is reduced to one N A DH. We're gonna say here that one carbon is lost as carbon dioxide. If we take a look here at our reaction, we have our pyruvate molecule. Here. Here, we've highlighted the carboxyl group of this pyruvate molecule we have here co um well, coenzyme A with its style group and we have N ad positive here, we would lose carbon dioxide and have the generation of N A DH. This would be helped by the enzyme pyruvate dehydrogenase. And in this process, we oxidize to become our acetyl coa molecule, right. So just remember this happens under aerobic respiration which, which can only occur when there's oxygen available.
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