Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
4. Genetic Mapping and Linkage
Trihybrid Cross
Problem 22aKlug - 12th Edition
Textbook Question
An organism of the genotype AaBbCc was testcrossed to a triply recessive organism (aabbcc). The genotypes of the progeny are presented in the following table.
20 AaBbCc 20 AaBbcc
20 aabbCc 20 aabbcc
5 AabbCc 5 Aabbcc
5 aaBbCc 5 aaBbcc
What can you conclude from the actual data about the location of the three genes in relation to one another?
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Identify the parental and recombinant genotypes from the progeny data. Parental genotypes are the most frequent, while recombinant genotypes are less frequent.
From the table, identify the parental genotypes as aaBbcc and AabbCc, as they have the highest numbers of progeny (55 and 43, respectively).
Identify the double recombinant genotypes, which are the least frequent. In this case, they are aabbCc and AaBbcc, with 3 and 5 progeny, respectively.
Determine the gene order by comparing the parental and double recombinant genotypes. The gene that differs between the parental and double recombinant genotypes is the middle gene.
Conclude the gene order based on the analysis of parental and double recombinant genotypes.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Testcross
A testcross is a genetic cross between an individual with an unknown genotype and a homozygous recessive individual. This method helps determine the genotype of the unknown individual based on the phenotypes of the offspring. In this case, the organism with genotype AaBbCc is crossed with aabbcc, allowing the observation of progeny ratios to infer gene linkage and arrangement.
Gene Linkage
Gene linkage refers to the tendency of genes located close to each other on a chromosome to be inherited together during meiosis. Linked genes do not assort independently, which can lead to deviations from expected Mendelian ratios in progeny. The analysis of progeny ratios from the testcross can reveal whether the genes A, B, and C are linked or assort independently.
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Chi Square and Linkage
Recombination Frequency
Recombination frequency is a measure of the likelihood that two genes will be separated during meiosis due to crossing over. It is calculated by dividing the number of recombinant offspring by the total number of offspring. A low recombination frequency indicates that genes are closely linked, while a higher frequency suggests they are further apart on the chromosome, providing insights into their relative positions.
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Related Practice
Textbook Question
Determine whether the statements below are true or false. If a statement is false, provide the correct information or revise the statement to make it correct.
The outcome of a trihybrid cross is predicted by the law of segregation.
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