Describe some cause(s) of muscle fatigue and define this term clearly.

Explain how a slight (but smooth) contraction differs from a vigorous contraction of the same muscle. Use the concepts of multiple motor unit summation.
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Key Concepts
Motor Units
Multiple Motor Unit Summation
Smooth vs. Vigorous Contraction
When a suicide victim was found, the coroner was unable to remove the drug vial clutched in his hand. Explain the reasons for this. If the victim had been discovered three days later, would the coroner have had the same difficulty? Explain.
Muscle-relaxing drugs are administered to a patient during major surgery. Which of the two chemicals described next would be a good skeletal muscle relaxant and why?
• Chemical A binds to and blocks ACh receptors of muscle cells.
• Chemical B floods the muscle cells' cytoplasm with Ca²⁺.
a. Describe the structure of a sarcomere and indicate the relationship of the sarcomere to myofilaments.
b. Explain the sliding filament model of contraction using appropriately labeled diagrams of a relaxed and a contracted sarcomere.
Smooth muscle has some unique properties, such as low energy usage, and the ability to maintain contraction over long periods. Tie these properties to the function of smooth muscle in the body.
