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Ch. 19 - Epigenetics

Chapter 18, Problem 23

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

How does acetylation of lysine affect its interaction with DNA, and how is this related to the activation of gene expression?

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Hello everyone and welcome to today's video. So which of the following compounds provides an a settled group during the asset elation of licensing. So let's analyze each of the compounds listed in order to determine this. Well, first of all, we have a D. P. We know that A D. P. Is a nucleotide that's involved in energy metabolism or the creation of energy. It is not going to be involved in the assimilation of license. So we're going to cancel this out and then we have N A D E and F A D. These are both electron carriers that again are going to be involved in energy metabolism because of this, we're going to cancel the mod as well. Then we have a settled CO A. And this is settled. It's going to be referring to the settled group that is present in the molecule. When this molecule is divided, it is going to let go of the assembled group and it is going to be providing it to license during a circulation because of this is going to be our correct answer choice. And we're going to highlight it as a final answer to our question. I really hope this video helped you and I hope to see you on the next one
Related Practice
Textbook Question

From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.

If not, how can you reconcile these differences?

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Textbook Question

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

Which category includes lysine?

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Textbook Question

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

How does this property of lysine allow it to interact with DNA?

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Textbook Question

A particular type of anemia in humans, called β-thalassemia, results from a severe reduction or absence of the normal β-globin chain of hemoglobin. However, the γ-globin chain, normally only expressed during fetal development, can functionally substitute for β-globin. A variety of studies have explored the use of the nucleoside 5-azacytidine for the expression of γ-globin in adult patients with β-thalassemia.

Explain why this drug may also have some adverse side effects.

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Textbook Question

A particular type of anemia in humans, called β-thalassemia, results from a severe reduction or absence of the normal β-globin chain of hemoglobin. However, the γ-globin chain, normally only expressed during fetal development, can functionally substitute for β-globin. A variety of studies have explored the use of the nucleoside 5-azacytidine for the expression of γ-globin in adult patients with β-thalassemia.

How might 5-azacytidine lead to expression of γ-globin in adult patients?

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Textbook Question

Methylation of H3K9 by itself silences genes, but if H3K4 and H4K20 are also methylated, the combination of modifications stimulates transcription. What conclusions can you draw about this?

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