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Ch. 19 - Epigenetics

Chapter 18, Problem 22

From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.

If not, how can you reconcile these differences?

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Hello everyone and welcome to today's video. So which his stone age three modification is necessary for the chrome 18 remodeling complexes to be recruited to the promoter regions of the genes. Let's go over Each of our answer choices so that we may solve this problem. Let's begin by answer choice. The phosphor relation of age three is 10. Or remember from previous videos that the phosphor relation of this region is going to be a post transcription modification. Because of this it is not going to be involved in their recruiting of these chromatic remodeling complexes. So we're going to cancel this. Then we have B and C. The assimilation of H three K nine and the methylation of H three K 36. These have been actively found to be involved in gene expression. However, there is no evidence that they are necessary for chromatic remodeling complexes to be recruited. So we're going to cancel both of them out. Then we have methylation of H three K four. This is going to be or correct answer choice because this age three modification is going to be necessary for cremating remodeling complexes to be recruited to the promoting regions of genes. So we're going to highlight that as the correct answer to our question. I really hope this video helped you and I hope to see you on the next one
Related Practice
Textbook Question

Because the degree of DNA methylation appears to be a relatively reliable genetic marker for some forms of cancer, researchers have explored the possibility of altering DNA methylation as a form of cancer therapy. Initial studies indicate that while hypomethylation suppresses the formation of some tumors, other tumors thrive. Why would one expect different cancers to respond differently to either hypomethylation or hypermethylation therapies?

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Textbook Question

From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.

Are there any overlaps on the lists?

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Textbook Question

From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.

Are these overlaps explained by different modifications?

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Textbook Question

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

Which category includes lysine?

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Textbook Question

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

How does this property of lysine allow it to interact with DNA?

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Textbook Question

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

How does acetylation of lysine affect its interaction with DNA, and how is this related to the activation of gene expression?

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