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Ch. 19 - Epigenetics

Chapter 18, Problem 22

From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.

Are these overlaps explained by different modifications?

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Hello everyone and welcome to today's video. So which of the following modifications of Histone H3 is associated with the formation of hetero protein and gene silencing. Remember that when we form Hetero Comitan were pro preventing gene expression. So keep that in mind as we solve our problem. Let's go over answer choices and be first because we have a circulation. Remember that as circulation is heavily related to the formation of a chromatic which is going to promote gene expression. It is not going to be hetero chromatic informed here. So we're going to cancel both of these out. Then we have the we have the methylation of H three K 27. Well this is actually going to be related to gene silencing and it is going to be forming head or chromatic. However it is not going to be forming pure head or chroma team is going to be firming something called ulcerative hetero clementine which has many other properties because of this. We're going to cancel this out and then we have the methylation of H three K nine. This is going to be or correct answer choice because it is going to be related to gene silencing as methylation is but also it is going to be forming purely hetero commenting because of this. We're going to highlight answer choice e as the correct answer to our question. I really hope this video helped you and I hope to see you on the next one
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Textbook Question

Prader–Willi syndrome (PWS) is a genetic disorder with a clinical profile of obesity, intellectual disability, and short stature. It can be caused in several ways. Most common is a deletion on the paternal copy of chromosome 15, but it can also be caused by an epigenetic imprinting disorder, and uniparental disomy, an event in which the affected child receives two copies of the maternal chromosome 15. A child with PWS comes to your clinic for a diagnosis of the molecular basis for this condition. The gel below shows the results of testing with short tandem repeats (STRs) from the region of chromosome 15 associated with the disorder.

Based on your interpretation of the data, what is the cause of PWS in this case? Explain your reasoning. 

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Textbook Question

Because the degree of DNA methylation appears to be a relatively reliable genetic marker for some forms of cancer, researchers have explored the possibility of altering DNA methylation as a form of cancer therapy. Initial studies indicate that while hypomethylation suppresses the formation of some tumors, other tumors thrive. Why would one expect different cancers to respond differently to either hypomethylation or hypermethylation therapies?

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Textbook Question

From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.

Are there any overlaps on the lists?

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Textbook Question

From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.

If not, how can you reconcile these differences?

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Textbook Question

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

Which category includes lysine?

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Textbook Question

Amino acids are classified as positively charged, negatively charged, or electrically neutral.

How does this property of lysine allow it to interact with DNA?

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