Chapter 18, Problem 23
Amino acids are classified as positively charged, negatively charged, or electrically neutral.
Which category includes lysine?
Video transcript
From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.
Are there any overlaps on the lists?
From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.
Are these overlaps explained by different modifications?
From the data in Table 19.3, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.
If not, how can you reconcile these differences?
Amino acids are classified as positively charged, negatively charged, or electrically neutral.
How does this property of lysine allow it to interact with DNA?
Amino acids are classified as positively charged, negatively charged, or electrically neutral.
How does acetylation of lysine affect its interaction with DNA, and how is this related to the activation of gene expression?
A particular type of anemia in humans, called β-thalassemia, results from a severe reduction or absence of the normal β-globin chain of hemoglobin. However, the γ-globin chain, normally only expressed during fetal development, can functionally substitute for β-globin. A variety of studies have explored the use of the nucleoside 5-azacytidine for the expression of γ-globin in adult patients with β-thalassemia.
Explain why this drug may also have some adverse side effects.