A particular type of anemia in humans, called β-thalassemia, results from a severe reduction or absence of the normal β-globin chain of hemoglobin. However, the γ-globin chain, normally only expressed during fetal development, can functionally substitute for β-globin. A variety of studies have explored the use of the nucleoside 5-azacytidine for the expression of γ-globin in adult patients with β-thalassemia.

How might 5-azacytidine lead to expression of γ-globin in adult patients?

Video transcript

Hello everyone. Let's look at our next question. It says. Which of the following nucleotides is methylated at position five. And you carry outs. When we think about DNA methylation, the base that is methylated is choice C cytosine and that methylation of course is very important in the epigenetic modification of DNA. And the methyl group on the side is seen sort of protrudes into the major groove of the D. N. A. Helix. As a result it doesn't interfere with the base pairing that keeps that double helical structure. Um And the way it is involved in epigenetic modification is that the presence of that method group on the side A. Zine inhibits transcription. So methylation or di methylation can affect the expression of different genes and that's how it's involved in that epigenetic modification Of different genes. So again, which of the following nucleotides is methylated opposition five. And you carry outs and the answer is choice c cytosine. See you in the next video