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Ch. 19 - Epigenetics
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All textbooksKlug 12th EditionCh. 19 - EpigeneticsProblem 24

Chapter 18, Problem 24

Methylation of H3K9 by itself silences genes, but if H3K4 and H4K20 are also methylated, the combination of modifications stimulates transcription. What conclusions can you draw about this?

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Hello everyone and welcome to today's video. So which histone H. Three modification is related to M. RNA processing and transcription elongation. And so we're giving certain epigenetic modifications that could relate to this. Now let's analyze each answer choice and determine which one is related to M. RNA processing and transcription elongation. But as it turns out, answer choice is A. B and C. Are not going to be related to M. RNA processing and transcription elongation because it was for relation of H. Three S. 10. Their circulation of age three K 14 and the methylation of H three K four are going to be related to gene activation, the only epigenetic modification this state that is going to be related to M. RNA processing and transcription elongation is going to be this methylation of age three K. 36. So we're going to highlight the answer choice as a correct answer to our question. I really hope this video helped you and I hope to see you on the next one.
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How does acetylation of lysine affect its interaction with DNA, and how is this related to the activation of gene expression?

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A particular type of anemia in humans, called β-thalassemia, results from a severe reduction or absence of the normal β-globin chain of hemoglobin. However, the γ-globin chain, normally only expressed during fetal development, can functionally substitute for β-globin. A variety of studies have explored the use of the nucleoside 5-azacytidine for the expression of γ-globin in adult patients with β-thalassemia.

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Textbook Question

A particular type of anemia in humans, called β-thalassemia, results from a severe reduction or absence of the normal β-globin chain of hemoglobin. However, the γ-globin chain, normally only expressed during fetal development, can functionally substitute for β-globin. A variety of studies have explored the use of the nucleoside 5-azacytidine for the expression of γ-globin in adult patients with β-thalassemia.

How might 5-azacytidine lead to expression of γ-globin in adult patients?

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Textbook Question

DNA methylation is commonly associated with a reduction of transcription. The following data come from a study of the impact of the location and extent of DNA methylation on gene activity in eukaryotic cells. A bacterial gene, luciferase, was inserted into plasmids next to eukaryotic promoter fragments. CpG sequences, either within the promoter and coding sequence (transcription unit) or outside of the transcription unit, were methylated to various degrees, in vitro. The chimeric plasmids were then introduced into cultured cells, and luciferase activity was assayed. These data compare the degree of expression of luciferase with differences in the location of DNA methylation [Irvine et al. (2002). Mol. and Cell. Biol. 22:6689–6696]. What general conclusions can be drawn from these data? 


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