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Ch. 19 - Epigenetics

Chapter 18, Problem 19

A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.

Does this exclude genetic mutations as a cause of this condition?

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Hello everyone here we have a question asking us to choose the best statement that correctly describes Spina Bifida. A thesis with a neural tube defect detected early gestation, having associate chromosome abnormality. This is true. Up to 10% of fetuses with Spina Bifida, which were detected during the first trimester, also had an additional chromosome anomaly. So A. Is true. Be low socioeconomic status is associated with a higher risk of neural tube defects in many populations. This is true and that's because there's a higher incidence of lack of access to adequate medical care and the incapacity to procure foods and supplements that are needed by pregnant women. So B. Is true. C. Folic acid deficiency during the third trimester is the major cause of spina bifida. This is incorrect. The formation of the neural tube is accomplished during the first trimester. So timing of folic acid supplementation should be focused before or during the first trimester pregnancy sexy is incorrect. Which makes eat incorrect. So our answer here is the A. And B. Only. Thank you for watching. Bye.
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How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?

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How are mutations in histone acetylation (HAT) genes linked to cancer?

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A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.

What does this suggest about the cause of spina bifida?

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Textbook Question

A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.

Should researchers be looking for mutant alleles of genes that control formation and differentiation of the neural tube?

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Textbook Question

Trace the relationship between the methylation status of the glucocorticoid receptor gene and the behavioral response to stress.

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Textbook Question

Prader–Willi syndrome (PWS) is a genetic disorder with a clinical profile of obesity, intellectual disability, and short stature. It can be caused in several ways. Most common is a deletion on the paternal copy of chromosome 15, but it can also be caused by an epigenetic imprinting disorder, and uniparental disomy, an event in which the affected child receives two copies of the maternal chromosome 15. A child with PWS comes to your clinic for a diagnosis of the molecular basis for this condition. The gel below shows the results of testing with short tandem repeats (STRs) from the region of chromosome 15 associated with the disorder.

Is this case caused by a deletion in the paternal copy of chromosome 15? Explain.


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