Chapter 18, Problem 17
How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?
Video transcript
What is the role of imprinting in human genetic disorders?
Imprinting disorders do not involve changes in DNA sequence, but only the methylated state of the DNA. Does it seem likely that imprinting disorders could be treated by controlling the maternal environment in some way, perhaps by dietary changes?
Should fertility clinics be required by law to disclose that some assisted reproductive technologies (ARTs) can result in epigenetic diseases? How would you and your partner balance the risks of ART with the desire to have a child?
How are mutations in histone acetylation (HAT) genes linked to cancer?
A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
What does this suggest about the cause of spina bifida?
A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
Does this exclude genetic mutations as a cause of this condition?