Organic Chemistry
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Identify the carbonyl that would react more quickly with a nucleophile.
Determine whether the following species is a strong, intermediate, or weak nucleophile. Would this nucleophile add directly to a carbonyl or wait for the carbocation formation before adding to the carbonyl?
2-pentanone is more reactive and more electrophilic compared to methyl butyrate. Explain.
Determine whether the below-given species is a strong, intermediate, or weak nucleophile. Would this nucleophile add directly to a carbonyl or wait for the carbocation formation before adding to the carbonyl?
Can the incoming nucleophile add to the third carbon? Explain your answer.
Nucleophilic addition can occur at carbon 2 or carbon 4 of the given α,β-unsaturated ketone. Explain why.
Draw the product for the reaction of 3-ethyl-2-cyclopentenone with (i) HBr and (ii) CH3SH.
Identify from the given set of carbonyls, under basic conditions, which will react fastest and the slowest toward nucleophilic addition.
Indicate from the given set of carbonyls, under basic conditions, which will react fastest and the slowest toward nucleophilic addition.
Provide a reaction scheme for synthesizing the following compounds. Start with acetylene and use any additional reagents.
(i) (ii)
Among the compounds below, choose the one expected to react the fastest and the one expected to react the slowest toward a nucleophilic addition reaction in basic conditions.
Propose a synthesis for the following conversion.
1-cyclohexylethanone → 2-cyclohexyl-2-hydroxypropanoic acid
Illustrate the reaction mechanism for the following:
What is the product of the aldehyde addition below?