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Ch. 9 - Extranuclear Inheritance
Chapter 9, Problem 1

In this chapter, we focused on extranuclear inheritance and how traits can be determined by genetic information contained in mitochondria and chloroplasts, and we discussed how expression of maternal genotypes can affect the phenotype of an organism. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions?

What observations support the endosymbiotic theory?

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span>Step 1: Understand the endosymbiotic theory, which proposes that mitochondria and chloroplasts originated as free-living bacteria that were engulfed by ancestral eukaryotic cells.</span
span>Step 2: Identify the key observations that support this theory, such as the presence of double membranes around mitochondria and chloroplasts, which is consistent with the engulfing mechanism.</span
span>Step 3: Consider the genetic evidence, such as the fact that mitochondria and chloroplasts contain their own circular DNA, similar to bacterial genomes, and replicate independently of the cell's nuclear DNA.</span
span>Step 4: Examine the similarities in ribosomes and protein synthesis machinery between mitochondria, chloroplasts, and bacteria, which further supports their bacterial origin.</span
span>Step 5: Review the phylogenetic analyses that show mitochondria and chloroplasts are closely related to specific groups of bacteria, such as proteobacteria and cyanobacteria, respectively.</span

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Endosymbiotic Theory

The endosymbiotic theory posits that certain organelles, specifically mitochondria and chloroplasts, originated from free-living prokaryotic organisms that were engulfed by ancestral eukaryotic cells. This theory explains how these organelles have their own DNA, which is similar to bacterial DNA, supporting the idea that they were once independent entities. The theory is crucial for understanding the evolution of eukaryotic cells and the role of these organelles in cellular function.
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Extranuclear Inheritance

Extranuclear inheritance refers to the transmission of genetic material that occurs outside the nucleus, primarily through organelles like mitochondria and chloroplasts. This type of inheritance is typically maternal, meaning that offspring inherit these organelles and their associated genes from the mother. Understanding this concept is essential for analyzing how traits can be influenced by maternal genotypes and how they differ from Mendelian inheritance patterns.
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Phenotype and Maternal Genotypes

The phenotype of an organism is the observable physical or biochemical characteristics determined by its genotype and environmental influences. Maternal genotypes can significantly affect the phenotype of offspring, especially in cases of extranuclear inheritance, where traits linked to mitochondrial or chloroplast DNA are passed down. This relationship highlights the importance of maternal contributions to the genetic makeup and traits of the next generation.
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Related Practice
Textbook Question

In this chapter, we focused on extranuclear inheritance and how traits can be determined by genetic information contained in mitochondria and chloroplasts, and we discussed how expression of maternal genotypes can affect the phenotype of an organism. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions?

How did the discovery of three categories of petite mutations in yeast lead researchers to postulate extranuclear inheritance of colony size?

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Textbook Question

Streptomycin resistance in Chlamydomonas may result from a mutation in either a chloroplast gene or a nuclear gene. What phenotypic results would occur in a cross between a member of an mt⁺ strain resistant in both genes and a member of a strain sensitive to the antibiotic? What results would occur in the reciprocal cross?

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Textbook Question

What is the endosymbiotic theory, and why is this theory relevant to the study of extranuclear DNA in eukaryotic organelles?

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Textbook Question

Mutations in mitochondrial DNA appear to be responsible for a number of neurological disorders, including myoclonic epilepsy and ragged-red fiber disease, Leber's hereditary optic neuropathy, and Kearns-Sayre syndrome. In each case, the disease phenotype is expressed when the ratio of mutant to wild-type mitochondria exceeds a threshold peculiar to each disease, but usually in the 60 to 95 percent range.

Given that these are debilitating conditions, why has no cure been developed? Can you suggest a general approach that might be used to treat, or perhaps even cure, these disorders?

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