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Ch. 24 - Cancer Genetics

Chapter 23, Problem 6

What is the difference between saying that cancer is inherited and saying that the predisposition to cancer is inherited?

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Welcome back everyone. Here's the next question. Which of the following is not a tumor predisposition syndrome. So let's look at our answer choices here, we'll start with choice a early onset familial breast cancer. And this is a tumor predisposition syndrome, most often due to mutations in the B. R. C. A. One and two genes which does cause a predisposition towards early onset breast cancer as well as early onset ovarian cancer. So this is we're looking for one that is not a tumor predisposition syndrome. So Choice A is not our answer. Choice B is retinoblastoma, and retinoblastoma is caused by a genetic mutation that causes an increased risk of eye cancer at a young age along with several other forms of cancer. So since that's a tumor predisposition syndrome, it's also an honor answer choice C lee from Mountie syndrome. Uh And this is a rare genetic disorder caused by a mutation in the P 53 gene. P 53 being producing a protein that is a tumor suppressor protein. So, as you might expect, a mutation in a tumor suppressor protein uh causes a very high risk of cancer. It causes a 50% chance of cancer before the age of 30 and individuals with the syndrome and a 90% chance of cancer over a lifetime. So choice see also a predisposition syndrome. And so therefore not an answer. So we're down to choice D Bell's palsy. Um that is our answer. Bell's palsy is not a tumor predisposition syndrome. Bell's palsy is a sudden weakness of the muscles on one side of the face and it's not 100% sure what the causes. It's thought that it's caused by the swelling and inflammation of the cranial nerve. But in that case, obviously not a tumor predisposition syndrome doesn't cause any increased risk of cancer. So which of the following is not a tumor predisposition syndrome. And that's choice. D. Bell's palsy. See you in the next video.