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Ch. 16 - Regulation of Gene Expression in Bacteria

Chapter 16, Problem 12

Describe the role of attenuation in the regulation of tryptophan biosynthesis.

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Hello everyone. Let's look at our next question. It says. Attenuation is the process in which tryptophan regulates transcription and translation. Why is attenuation very important for bacteria. So we see that. Our question reminds us that tryptophan is able to regulate both transcription and translation. And how can that occur. And that's because in bacteria as we recall bacteria being pro carry outs have no nucleus. And of course when you carry out the nucleus is what separates the process of transcription and translation transcription taking place in the nucleus translation in the cytoplasm. But since bacteria have no nucleus transcription and translation happened simultaneously so the process of attenuation allows both of those processes to be regulated at the same time. Um So that's why the process of attenuation is specifically important. Since you haven't separated the two processes you need something that can regulate both processes happening at once. So that our answer here would be choice A because their transcription and translation happened simultaneously. Let's look at our other answer choices. Choice B says because they have an insufficient concentration of tryptophan in their system. Well this is not our correct answer. Um This process depends on the level of tryptophan. So there may be plenty of tryptophan um in the bacteria when there are high levels of tryptophan transcription is interrupted or attenuated. Um low levels of tryptophan cause transcription to be completed. So the bacteria don't have an insufficient concentration. Um They use this this system to regulate so that they're only making tryptophan when it's needed choice, he says because they cannot do protein synthesis without it. Um That's not our correct answer. Um That's not why you have this particular regulation, Choice D. Says. Because they do not have a transcription process due to their size. Well that's definitely not correct. Bacteria need to be able to produce proteins and therefore they have to transcribe D. N. A. Into RNA to then be translated into protein. So Choice D. Is not correct. So again, why is attenuation very important for bacteria as choice A. Because their transcription and translation happens simultaneously. See you in the next video.
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Attenuation of the trp operon was viewed as a relatively inefficient way to achieve genetic regulation when it was first discovered in the 1970s. Since then, however, attenuation has been found to be a relatively common regulatory strategy. Assuming that attenuation is a relatively inefficient way to achieve genetic regulation, what might explain its widespread occurrence?
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