Ch. 15 - Gene Mutation, DNA Repair, and Transposition
Chapter 15, Problem 12
Why are X rays more potent mutagens than UV radiation?
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Textbook Question
In studies of the amino acid sequence of wild-type and mutant forms of tryptophan synthetase in E. coli, the following changes have been observed:
Determine a set of triplet codes in which only a single-nucleotide change produces each amino acid change.
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Textbook Question
Contrast and compare the mutagenic effects of deaminating agents, alkylating agents, and base analogs.
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Textbook Question
Why are frameshift mutations likely to be more detrimental than point mutations, in which a single pyrimidine or purine has been substituted?
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Textbook Question
DNA damage brought on by a variety of natural and artificial agents elicits a wide variety of cellular responses involving numerous signaling pathways. In addition to the activation of DNA repair mechanisms, there can be activation of pathways leading to apoptosis (programmed cell death) and cell-cycle arrest. Why would apoptosis and cell-cycle arrest often be part of a cellular response to DNA damage?
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Textbook Question
A glycine residue is in position 210 of the tryptophan synthetase enzyme of wild-type E. coli. If the codon specifying glycine is GGA, how many single-base substitutions will result in an amino acid substitution at position 210? What are they? How many will result if the wild-type codon is GGU?
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Textbook Question
Contrast the various types of DNA repair mechanisms known to counteract the effects of UV radiation. What is the role of visible light in repairing UV-induced mutations?
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