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Ch. 12 - DNA Organization in Chromosomes

Chapter 12, Problem 12

Mammals contain a diploid genome consisting of at least 10⁹ bp. If this amount of DNA is present as chromatin fibers, where each group of 200 bp of DNA is combined with 9 histones into a nucleosome and each group of 6 nucleosomes is combined into a solenoid, achieving a final packing ratio of 50, determine (a) the total number of nucleosomes in all fibers, (b) the total number of histone molecules combined with DNA in the diploid genome, and (c) the combined length of all fibers.

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Hello, everyone and welcome to today's video. So we are aware that the total number of bases in mammal diploid cells is 6.6 times 10 to the ninth. And that the typical nucleosome contains 200 bases of DNA. Then the number of nucleosome in a mammalian cell is which of the following numbers. So in order to solve this problem, we just need to do some math and here's the equation for it. So the number of nucleus OMs, in this case in a mammalian cell is going to be equal to the total number of base pairs divided by the number of bases per nucleus zom. So let's write that down, we have the number of nucleus zones is going to be equal to 6.6 times 10 to the ninth divided by 200. And if we make this calculation, we're going to get the number 33 million and that is going to be represented by answer choice. See, I really hope this video helped you and I hope to see you on the next one.
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