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Ch. 12 - DNA Organization in Chromosomes
Chapter 12, Problem 6

During what genetic process are lampbrush chromosomes present in vertebrates?

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1
Understand that lampbrush chromosomes are a special form of chromosome found in the oocytes (immature egg cells) of most vertebrates, except mammals.
Recognize that these chromosomes are characterized by their large size and extensive looping, which makes them resemble a brush used for cleaning lamps.
Identify that lampbrush chromosomes are visible during a specific stage of meiosis, the process of cell division that reduces the chromosome number by half, leading to the production of gametes (sperm and eggs).
Focus on the fact that lampbrush chromosomes are present during the diplotene stage of prophase I of meiosis, where homologous chromosomes are paired and crossing over occurs.
Note that the loops of lampbrush chromosomes are sites of active transcription, where RNA synthesis is taking place, which is crucial for the development of the oocyte.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Lampbrush Chromosomes

Lampbrush chromosomes are specialized structures found in the oocytes of certain vertebrates during the diplotene stage of prophase I of meiosis. They are characterized by their large size and extended loops, which are sites of active transcription. This unique morphology allows for the synthesis of RNA, facilitating the production of proteins necessary for oocyte development.
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Meiosis

Meiosis is a type of cell division that reduces the chromosome number by half, resulting in the formation of gametes (sperm and eggs). It consists of two sequential divisions: meiosis I and meiosis II. During meiosis I, homologous chromosomes are separated, while meiosis II resembles mitosis, separating sister chromatids. Lampbrush chromosomes are specifically observed during the first meiotic prophase.
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Prophase I

Prophase I is the first stage of meiosis, where homologous chromosomes pair up and exchange genetic material through a process called crossing over. This stage is crucial for genetic diversity, as it allows for the recombination of alleles. Prophase I is divided into several sub-stages, with the diplotene stage being notable for the presence of lampbrush chromosomes, indicating active gene expression.
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