2. Mendel's Laws of Inheritance
Probability and Genetics
3:28 minutes
Problem 25a
Textbook Question
Textbook QuestionA 'wrongful birth' case was recently brought before a court in which a child with Smith–Lemli–Opitz syndrome was born to apparently healthy parents. This syndrome is characterized by a cluster of birth defects including cleft palate, and an array of problems with the reproductive and urinary organs. Originally considered by their physician as having a nongenetic basis, the parents decided to have another child, who was also born with Smith–Lemli–Opitz syndrome. In the role of a genetic counselor, instruct the court about what occurred, including the probability of the parents having two affected offspring, knowing that the disorder is inherited as a recessive trait. What is the probability that one of them is a carrier and the other is not? [Hint: The p values in (b), (c), and (d) should equal 1.]
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