One of the major causes of sickness, death, and economic loss in the cattle industry is Mannheimia haemolytica, which causes bovine pasteurellosis, or shipping fever. Noninvasive delivery of a vaccine using transgenic plants expressing immunogens would reduce labor costs and trauma to livestock. An early step toward developing an edible vaccine is to determine whether an injected version of an antigen (usually a derivative of the pathogen) is capable of stimulating the development of antibodies in a test organism. The following table assesses the ability of a transgenic portion of a toxin (Lkt) of M. haemolytica to stimulate development of specific antibodies in rabbits.

Immunogen Injected Antibody Production in Serum
Lkt50*—saline extract +
Lkt50*—column extract +
Mock injection -
*Lkt50 is a smaller derivative of Lkt that lacks all hydrophobic regions. indicates at least 50 percent neutralization of toxicity of Lkt; indicates no neutralization activity.
Source: Modified from Lee et al. (2001). Infect. and Immunity 69:5786–5793.

With regards to development of a usable edible vaccine, what work remains to be done?

Question

One of the major causes of sickness, death, and economic loss in the cattle industry is Mannheimia haemolytica, which causes bovine pasteurellosis, or shipping fever. Noninvasive delivery of a vaccine using transgenic plants expressing immunogens would reduce labor costs and trauma to livestock. An early step toward developing an edible vaccine is to determine whether an injected version of an antigen (usually a derivative of the pathogen) is capable of stimulating the development of antibodies in a test organism. The following table assesses the ability of a transgenic portion of a toxin (Lkt) of M. haemolytica to stimulate development of specific antibodies in rabbits.

Immunogen Injected Antibody Production in Serum
Lkt50*—saline extract +
Lkt50*—column extract +
Mock injection -
*Lkt50 is a smaller derivative of Lkt that lacks all hydrophobic regions. indicates at least 50 percent neutralization of toxicity of Lkt; indicates no neutralization activity.
Source: Modified from Lee et al. (2001). Infect. and Immunity 69:5786–5793.

With regards to development of a usable edible vaccine, what work remains to be done?

Accepted Answer

Hey, everyone. Let's take a look at this question together, identify the incorrect statement about edible vaccines. So let's recall what we've learned about edible vaccines to figure out which of the following statements is incorrect. So some things that we know about edible vaccines is that they are keet stable, they are keep to produce, they do not require refrigeration and they do not need to be administered under sterile condition. And we also know that they can be synthesized in edible food plants. So looking at the following statements, let's try to identify the incorrect statement. And so looking at the following statements, we can see that answer choice C so they are not heat stable, which we know edible vaccines are heat stable. And so that means that answer choice C is an incorrect statement which makes it the correct answer because we're low looking for the incorrect statement about edible vaccines. And we know that edible vaccines are in fact heat stable. Don't answer choice C is an incorrect statement. Making it the correct answer to this question. I hope you found this video to be helpful. Thank you and goodbye.

Verified Solution

Key Concepts

Transgenic Plants

Antibody Production

Edible Vaccines