What are the major mechanisms of epigenetic genome modification?

Video transcript

Hi, everybody. Let's take a look at this practice problem together. Which of the following is not an epigenetic genome modification. Let's recall when an epigenetic modification is. Now that type of modification is where you modify the D N A without changing the D N A sequence. So let's take a look at our options. We've got a DNA methylation. So this is the addition of a methyl group onto D N A and this does not alter the sequence of D N A. Therefore, this is an example of epigenetic modification. So A is not the correct answer. Then we've got B histone methylation. This is the addition of a methyl group onto the histone protein. This is also an example of an epigenetic modification because you don't get any alteration of the sequence of the DNA sequence. So B is also not the correct answer. Now, let's discuss option D Crow Metin remodeling. So recall that this is when crow metin goes through restructuring, usually it is packed genomic DNA and so you get restructuring of it. However, there are no alteration of the sequence and therefore D is also not the correct answer. So the correct answer is C genetic mutation, mutations permanently change D N A. So they permanently change the D N A sequence. Therefore, they are not epigenetic modifications. And C is the correct answer. Alright. Everybody, I hope you found this helpful and I'll see you soon for the next practice problem.