Chapter 18, Problem 1
In this chapter, we focused on epigenetic modifications to the genome that regulate gene expression. Several mechanisms are involved, and epigenetic control of gene expression is important in development, cancer, and modulating the genomic response to environmental factors. From the explanations given in the chapter,
What is the evidence that epigenetic changes are involved in cancer?
Video transcript
In this chapter, we focused on epigenetic modifications to the genome that regulate gene expression. Several mechanisms are involved, and epigenetic control of gene expression is important in development, cancer, and modulating the genomic response to environmental factors. From the explanations given in the chapter,
How does an environmental factor like stress generate a response that is transmitted from generation to generation?
In this chapter, we focused on how eukaryotic gene expression is regulated posttranscriptionally. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter:
How do we know that microRNAs negatively regulate target mRNAs?
In this chapter, we focused on epigenetic modifications to the genome that regulate gene expression. Several mechanisms are involved, and epigenetic control of gene expression is important in development, cancer, and modulating the genomic response to environmental factors. From the explanations given in the chapter,
How do we know how methylation of promoters silences gene expression?
Write a short essay describing how epigenetic changes in cancer cells contribute to the development and maintenance of cancers.
What are the major mechanisms of epigenetic genome modification?
What parts of the genome are reversibly methylated? How does this affect gene expression?