Present an overview of RNA interference (RNAi). How does the silencing process begin, and what major components participate?

Question

Accepted Answer

Hello everyone. Let's look at our next problem. It says RNA interference or RNA I. Is a mechanism by which cells can regulate gene expression. RNA I silences gene expression by binding and degrading and then we have four different choices here. Choice A T RNA molecules. B M RNA molecules see initiation complex or D. DNA molecules. Let's recall from our content video, the mechanism by which RNA I works. Um RNA I uses small RNA fragments or sequences called S. I. R. N. A. Short interfering RNA or micro R N. A M I R N A. And these short little D. N. A sequences enter the cell where they then bind to a complementary RNA sequence. They combine with a protein called risk which stands for RNA interfering silence and complex. At that point they can bond with their complementary sequence on M. RNA strand and once they have bound to that complementary sequence that silencing complex then degrades that particular piece of M. R. N. A, resulting in a silencing or reduction of gene expression. So we can look back at our answer choices then and see that our correct answer here is choice B. M. RNA molecules. These small S. I. R N. A. R. M I. R. A. And combined with that silencing complex bind to the M. RNA transcript to down regulate or silence gene expression. See you in the next video

Present an overview of RNA interference (RNAi). How does the silencing process begin, and what major components participate?

Verified Solution

Key Concepts

RNA Interference (RNAi)

Dicer and siRNA

RNA-Induced Silencing Complex (RISC)