Skip to main content
Ch. 12 - DNA Organization in Chromosomes
Chapter 12, Problem 13

Assume that a viral DNA molecule is a 50-µm-long circular strand with a uniform 20-Å diameter. If this molecule is contained in a viral head that is a 0.08-µm-diameter sphere, will the DNA molecule fit into the viral head, assuming complete flexibility of the molecule? Justify your answer mathematically.

Verified step by step guidance
1
Convert the length of the DNA molecule from micrometers to angstroms. Since 1 µm = 10,000 Å, multiply 50 µm by 10,000 Å/µm.
Calculate the volume of the DNA molecule. Use the formula for the volume of a cylinder: V = πr^2h, where r is the radius (half of the diameter) and h is the length of the DNA.
Convert the diameter of the viral head from micrometers to angstroms. Since 1 µm = 10,000 Å, multiply 0.08 µm by 10,000 Å/µm.
Calculate the volume of the viral head. Use the formula for the volume of a sphere: V = (4/3)πr^3, where r is the radius (half of the diameter).
Compare the volume of the DNA molecule to the volume of the viral head to determine if the DNA can fit inside.

Verified Solution

Video duration:
2m
This video solution was recommended by our tutors as helpful for the problem above.
Was this helpful?

Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Molecular Dimensions

Understanding the dimensions of both the viral DNA and the viral head is crucial. The DNA is a circular strand measuring 50 µm in length and 20 Å in diameter, while the viral head is a sphere with a diameter of 0.08 µm. Converting these measurements into consistent units is essential for accurate comparison.
Recommended video:
Guided course
07:11
Mapping with Markers

Geometric Fitting

Geometric fitting involves determining whether one shape can fit within another based on their dimensions. In this case, we need to assess if the circular DNA strand can be accommodated within the spherical viral head, considering the DNA's flexibility and the head's volume.
Recommended video:
Guided course
05:58
Natural Selection

Mathematical Justification

Mathematical justification requires applying formulas to calculate the volume of the viral head and the effective space occupied by the DNA. By comparing these values, we can determine if the DNA can fit inside the viral head, thus providing a quantitative basis for the conclusion.
Recommended video:
Guided course
11:10
Mathematical Measurements
Related Practice
Textbook Question
Describe the transitions that occur as nucleosomes are coiled and folded, ultimately forming a chromatid.
258
views
Textbook Question
Provide a comprehensive definition of heterochromatin and list as many examples as you can.
322
views
Textbook Question
Mammals contain a diploid genome consisting of at least 10⁹ bp. If this amount of DNA is present as chromatin fibers, where each group of 200 bp of DNA is combined with 9 histones into a nucleosome and each group of 6 nucleosomes is combined into a solenoid, achieving a final packing ratio of 50, determine (a) the total number of nucleosomes in all fibers, (b) the total number of histone molecules combined with DNA in the diploid genome, and (c) the combined length of all fibers.
363
views
Textbook Question
How many base pairs are in a molecule of phage T2 DNA 52-µm long?
448
views
Textbook Question
Examples of histone modifications are acetylation (by histone acetyltransferase, or HAT), which is often linked to gene activation, and deacetylation (by histone deacetylases, or HDACs), which often leads to gene silencing typical of heterochromatin. Such heterochromatinization is initiated from a nucleation site and spreads bidirectionally until encountering boundaries that delimit the silenced areas. Recall from earlier in the text (see Chapter 4) the brief discussion of position effect, where repositioning of the w⁺ allele in Drosophila by translocation or inversion near heterochromatin produces intermittent w⁺ activity. In the heterozygous state (w⁺/w) a variegated eye is produced, with white and red patches. How might one explain position-effect variegation in terms of histone acetylation and/or deacetylation?
531
views
Textbook Question
In a study of Drosophila, two normally active genes, w⁺ (wild-type allele of the white-eye gene) and hsp26 (a heat-shock gene), were introduced (using a plasmid vector) into euchromatic and heterochromatic chromosomal regions, and the relative activity of each gene was assessed [Sun et al. (2002)]. An approximation of the resulting data is shown in the following table. Which characteristic or characteristics of heterochromatin are supported by the experimental data? Gene Activity (relative percentage) _ Euchromatin Heterochromatin hsp26 100% 31% w⁺ 100% 8%
278
views