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Ch. 21 The Immune System: Innate and Adaptive Body Defenses
Chapter 20, Problem 21

Name several cytokines and describe their role in the immune response.

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Identify what cytokines are: Cytokines are small proteins that are crucial in controlling the growth and activity of other immune system cells and blood cells.
List several cytokines: Examples include interleukins (ILs), tumor necrosis factors (TNFs), interferons (IFNs), and chemokines.
Describe the role of interleukins: Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). They play a role in the differentiation and activation of immune cells.
Explain the function of tumor necrosis factors: TNFs are involved in systemic inflammation and are one of the cytokines that make up the acute phase reaction. They can induce fever, apoptotic cell death, and inflammation.
Discuss the role of interferons: Interferons are a group of signaling proteins made and released by host cells in response to the presence of viruses. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Cytokines

Cytokines are small proteins released by cells that have a specific effect on the interactions and communications between cells in the immune system. They play a crucial role in regulating immune responses, inflammation, and hematopoiesis. Different cytokines can promote or inhibit the activity of immune cells, influencing the overall response to pathogens.
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Cytokines

Types of Cytokines

Cytokines can be classified into several types, including interleukins, interferons, tumor necrosis factors, and chemokines. Each type has distinct functions; for example, interleukins are primarily involved in cell signaling, while interferons are critical for antiviral responses. Understanding these types helps in grasping how the immune system coordinates its response to infections.
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Types of Cytokines

Immune Response

The immune response is the body's defense mechanism against pathogens, involving a complex network of cells and signaling molecules. It can be categorized into innate immunity, which provides immediate but non-specific defense, and adaptive immunity, which develops a targeted response over time. Cytokines are essential in mediating and regulating both types of immune responses, ensuring an effective reaction to infections.
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