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Ch. 8 - Microbial Genetics
Chapter 8, Problem 8.4a

Bacteria can acquire antibiotic resistance by all of the following except
a. mutation.
b. insertion of transposons.
c. conjugation.
d. snRNPs.
e. transformation.

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1
Understand the mechanisms by which bacteria can acquire antibiotic resistance: mutation, insertion of transposons, conjugation, and transformation.
Recognize that mutation involves changes in the bacterial DNA sequence that can lead to resistance.
Identify that insertion of transposons involves mobile genetic elements that can carry resistance genes into the bacterial genome.
Recall that conjugation is a process where bacteria transfer genetic material, including resistance genes, through direct contact.
Note that transformation involves the uptake of free DNA from the environment by bacteria, which can include resistance genes.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Antibiotic Resistance Mechanisms

Antibiotic resistance in bacteria can occur through several mechanisms, including genetic mutations, horizontal gene transfer, and the acquisition of resistance genes. These mechanisms allow bacteria to survive exposure to antibiotics, making infections harder to treat. Understanding these processes is crucial for developing effective treatment strategies.
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Horizontal Gene Transfer

Horizontal gene transfer (HGT) is a process where bacteria exchange genetic material, contributing to antibiotic resistance. This can occur through transformation (uptake of free DNA), conjugation (direct transfer between bacteria), and transduction (transfer via bacteriophages). HGT plays a significant role in the rapid spread of resistance traits among bacterial populations.
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snRNPs (Small Nuclear Ribonucleoproteins)

snRNPs are components of the spliceosome involved in RNA splicing, a process that modifies pre-mRNA into mature mRNA. While they are essential for gene expression in eukaryotic cells, they do not play a role in bacterial antibiotic resistance mechanisms. Recognizing the distinction between cellular processes in prokaryotes and eukaryotes is important for understanding microbial genetics.
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