Which of the following statements about IFN- is false?
a. It interferes with viral replication.
b. It is host-cell–specific.
c. It is released by fibroblasts.
d. It is virus-specific.
e. It is released by lymphocytes.

Verified step by step guidance

1. Identify what IFN stands for: IFN refers to Interferon, a group of signaling proteins made and released by host cells in response to the presence of viruses.
2. Understand the role of Interferons: They are crucial in the immune response, particularly in inhibiting viral replication within host cells.
3. Analyze each statement: a) Interferons do interfere with viral replication, so this statement is true.
4. Consider the specificity: b) Interferons are host-cell–specific, meaning they are produced by the host's cells, not specific to the virus itself, so this statement is true.
5. Evaluate the virus-specificity: d) Interferons are not virus-specific; they act against a broad range of viruses, making this statement false.

Key Concepts

Interferon (IFN) Function

Interferons are a group of signaling proteins produced by host cells in response to viral infections. They play a crucial role in the immune response by interfering with viral replication within host cells, enhancing the ability of the immune system to fight off infections.

Host-Cell Specificity

Interferons exhibit host-cell specificity, meaning that their effects are primarily observed in the cells of the organism that produces them. This specificity is important for the regulation of immune responses and the protection of the host from viral pathogens.

Types of Interferons

There are different types of interferons, primarily classified into Type I (e.g., IFN-alpha and IFN-beta) and Type II (e.g., IFN-gamma). While Type I interferons are produced by various cells including fibroblasts and lymphocytes, Type II interferon is mainly produced by immune cells like T lymphocytes, highlighting the diverse sources and functions of these proteins.