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Ch.26 Nucleic Acids and Protein Synthesis
Chapter 26, Problem 26.69

There are different tRNAs for each amino acid. What is one major way to differentiate among the tRNAs for each amino acid?

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tRNAs are differentiated by their anticodon sequences, which are complementary to the mRNA codons.
Each tRNA molecule has a specific anticodon that pairs with a corresponding codon on the mRNA during protein synthesis.
The anticodon-codon pairing ensures that the correct amino acid is added to the growing polypeptide chain.
Additionally, tRNAs have specific structural features and modifications that help in their recognition by the correct aminoacyl-tRNA synthetase enzyme.
These enzymes are responsible for attaching the correct amino acid to its corresponding tRNA, further ensuring the fidelity of protein synthesis.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

tRNA Structure

Transfer RNA (tRNA) is a small RNA molecule that plays a crucial role in protein synthesis by transporting amino acids to the ribosome. Each tRNA has a specific three-dimensional structure that includes an anticodon region, which pairs with the corresponding codon on mRNA, and an acceptor stem where the amino acid is attached. The unique structure of each tRNA allows it to recognize and bind to its specific amino acid.
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Amino Acid Specificity

Each tRNA is linked to a specific amino acid through a process called aminoacylation, which is catalyzed by enzymes known as aminoacyl-tRNA synthetases. These enzymes ensure that the correct amino acid is attached to its corresponding tRNA, thus maintaining the fidelity of protein synthesis. The specificity of this attachment is a key factor in differentiating among the various tRNAs.
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Anticodon-Codon Interaction

The anticodon is a sequence of three nucleotides on the tRNA that is complementary to a specific codon on the mRNA. This interaction is essential for the accurate translation of genetic information into proteins. The unique sequence of the anticodon allows for the differentiation of tRNAs, as each tRNA recognizes a specific codon corresponding to its associated amino acid.
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