One complication of making a transgenic animal is that the transgene may integrate at random into the coding region, or the regulatory region, of an endogenous gene. What might be the consequences of such random integrations? How might this complicate genetic analysis of the transgene?

Video transcript

Hi, everybody. Let's take a look at this practice problem together which of the following statements about the transgenic animal is true. Now, recall that transgenic animals are animals that contain deliberately placed foreign DNA or genes. And transgenic organisms are often used to study human genes. So let's figure out which statement is true. We've got B, the gene of interest is disrupted. So the purpose of using a transgenic animal is to study the gene of interest. So we want that gene to remain intact and functional. Therefore, option B is incorrect. Then we've got option C, the gene undergoes homologous recombination in the host cell. Recall that the gene that was put into the transgenic animals genome is called the trans gene. And this is done using a vector. Well, it's the vector, not the transgene that undergoes homologous recombination in the host cell. Therefore, C is also incorrect. And because B and C are wrong answers, D all options are correct is wrong as well. Therefore, the correct answer is a, they express or over express a particular gene of interest because we use trans eic animals to study human genes. We want those genes to be expressed or over expressed for research purposes. So, a is the correct answer. All right, everybody. I hope you found this helpful and I'll see you soon for the next practice problem.