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Ch. 22 - Applications of Genetic Engineering and Biotechnology
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All textbooksKlug 12th EditionCh. 22 - Applications of Genetic Engineering and BiotechnologyProblem 23

Chapter 21, Problem 23

What is the difference between a knockout animal and a transgenic animal?

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Hello, everyone here We have a question asking which of the following is the main purpose of doing a gene knockout. The main purpose of a gene knockout is to disrupt or eliminate the gene of interest to determine the effect of its loss on the animals phenotype. So what they're doing is they're taking out a gene to see the animals phenotype without it. So the correct answer is a to identify what happens if the gene of interest is eliminated or disrupted. Thank you for watching. Bye.
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When disrupting a mouse gene by knockout, why is it desirable to breed mice until offspring homozygous (−/−) for the knockout target gene are obtained?

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A number of mouse models for human cystic fibrosis (CF) exist. Each of these mouse strains is transgenic and bears a different specific CFTR gene mutation. The mutations are the same as those seen in several varieties of human CF. These transgenic CF mice are being used to study the range of different phenotypes that characterize CF in humans. They are also used as models to test potential CF drugs. Unfortunately, most transgenic mouse CF strains do not show one of the most characteristic symptoms of human CF, that of lung congestion. Can you think of a reason why mouse CF strains do not display this symptom of human CF?

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