Chapter 20, Problem 9
What functional information about a genome can be determined through applications of chromatin immunoprecipitation (ChIP)?
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Annotation involves identifying genes and gene-regulatory sequences in a genome. List and describe characteristics of a genome that are hallmarks for identifying genes in an unknown sequence. What characteristics would you look for in a bacterial genome? A eukaryotic genome?
How do high-throughput techniques such as computer-automated, next-generation sequencing, and mass spectrometry facilitate research in genomics and proteomics? Explain.
BLAST searches and related applications are essential for analyzing gene and protein sequences. Define BLAST, describe basic features of this bioinformatics tool, and give an example of information provided by a BLAST search.
It can be said that modern biology is experiencing an 'omics' revolution. What does this mean? Explain your answer.
Metagenomics studies generate very large amounts of sequence data. Provide examples of genetic insight that can be learned from metagenomics.