Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development.

What evidence indicates that the eyeless gene is part of a developmental network?

Verified step by step guidance

1. Identify the role of the eyeless gene in Drosophila development, noting that it is crucial for eye formation.
2. Understand that the eyeless gene is homologous to the Pax6 gene in humans, which is also essential for eye development, indicating a conserved function across species.
3. Recognize that mutations in the eyeless gene result in the absence of eyes in Drosophila, demonstrating its necessity in the developmental network for eye formation.
4. Consider experiments where ectopic expression of the eyeless gene in non-eye tissues of Drosophila leads to the formation of eye structures, showing its sufficiency in initiating eye development.
5. Review genetic interaction studies that show the eyeless gene interacts with other genes in a network, coordinating the complex process of eye development.

Key Concepts

Eyeless Gene

The eyeless gene in Drosophila is a critical gene that regulates eye development. It encodes a transcription factor that initiates the formation of eye tissues. Mutations in this gene can lead to the absence of eyes, demonstrating its essential role in ocular development. Understanding its function provides insights into similar genetic mechanisms in other organisms, including humans.

Developmental Gene Networks

Developmental gene networks are interconnected groups of genes that work together to control the development of specific tissues and organs. These networks involve signaling pathways and regulatory interactions that ensure proper timing and spatial expression of genes during development. The eyeless gene is part of such a network, influencing and being influenced by other genes that contribute to eye formation.

Conservation of Genetic Pathways

Conservation of genetic pathways refers to the phenomenon where similar genetic mechanisms are preserved across different species through evolution. This concept suggests that studying model organisms like Drosophila can reveal fundamental biological processes applicable to humans. Evidence of the eyeless gene's role in eye development in fruit flies supports the idea that analogous genes may function similarly in human eye development.