Ch. 15 - Gene Mutation, DNA Repair, and Transposition
Chapter 15, Problem 8
When the amino acid sequences of insulin isolated from different organisms were determined, differences were noted. For example, alanine was substituted for threonine, serine for glycine, and valine for isoleucine at corresponding positions in the protein. List the single-base changes that could occur in codons of the genetic code to produce these amino acid changes.
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Why is a random mutation more likely to be deleterious than beneficial?
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Most mutations in a diploid organism are recessive. Why?
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In studies of the amino acid sequence of wild-type and mutant forms of tryptophan synthetase in E. coli, the following changes have been observed:
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Contrast and compare the mutagenic effects of deaminating agents, alkylating agents, and base analogs.
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