miRNAs target endogenous mRNAs in a sequence-specific manner. Explain, conceptually, how one might identify potential mRNA targets for a given miRNA if you only know the sequence of the miRNA and the sequence of all mRNAs in a cell or tissue of interest.

Video transcript

Hello everyone here we have a question asking us which for the following is a component of the RNA induced silencing complex, also known as R. I. S. See that contributes to the degradation of target M. RNA molecules. S I R N. A and M I R N. A. Are both little non coding RNA molecules that are involved in the control of gene expression. They work by attaching to certain messenger RNA molecules and either preventing or stimulating the breakdown of those M RNA molecules. The M I R N. A. Or S. I. RNA strand attaches to a protein called Argonaut, which functions as the catalytic component of the N. RNA induced silencing complex. The Argonaut protein recognizes and binds to compatible M RNA molecules by using the bound RNA strand as a guide and then the M R N. A. Is either prevented from being translated or is cleaved and destroyed. So the target M RNA molecules are degraded by both S. I R N. A. And M I R N A, which are components of the R. I S. C. So our answer here is D. Both S. I R N A. Nor am I R N. A. Thank you for watching. Bye.