In this chapter, we focused on how eukaryotic genes are regulated at the transcriptional level. Along the way, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, How do we know that there is an association between disease susceptibility in humans and regulatory DNA sequences?

Video transcript

Hi everyone. Let's take a look at the following practice problem together. The following our regulatory sequences in the D N A. Except so our answer should be a D N A sequence and it should regulate, meaning that it should control the transcription of D N A. Into R N A. And so let's take a look at our possible options. We've got a enhancers enhancers literally enhance or they increase the rate of transcription. And so A is not the correct answer, enhancers are part of the D N. A sequence. Then we've got B promoters. Now promoters are also part of the D. N. A sequence and they initiate transcription or promote transcription. So B is not the correct answer either. Next we've got C silencers. Now silencers do the opposite of enhancers. They silence or decrease the rate of transcription and they are also part of the D N. A sequence. So C. Is not correct. So our answer has to be de activators. Now recall that activators are a type of transcription factor and transcription factors are proteins. And so they are not a part of the D. N. A sequence and they're in proteins that increased transcription. And so de activators is the correct answer. Alright, everyone I hope you found this helpful and I'll see you soon for the next practice problem