Textbook Question
Compare and contrast promoters and enhancers with respect to their location (upstream versus downstream), orientation, and distance (in base pairs) relative to a gene they regulate.
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Ch. 13 - Regulation of Gene Expression in Eukaryotes
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 13, Problem 14
What is one proposed role for lncRNAs?
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Long non-coding RNAs (lncRNAs) are a type of RNA molecule that are longer than 200 nucleotides and do not code for proteins.
One proposed role for lncRNAs is in the regulation of gene expression at various levels, including chromatin modification, transcription, and post-transcriptional processing.
lncRNAs can act as molecular scaffolds, bringing together proteins and other molecules to form complexes that can modify chromatin structure and influence gene expression.
They can also function as decoys, binding to and sequestering proteins or other RNAs, thereby preventing them from interacting with their usual targets.
Additionally, lncRNAs may guide chromatin-modifying complexes to specific genomic locations, thereby influencing the transcriptional activity of nearby genes.
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Key Concepts
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Long Non-Coding RNAs (lncRNAs)
Long non-coding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and do not encode proteins. They play crucial roles in regulating gene expression at various levels, including chromatin remodeling, transcription, and post-transcriptional processing. Their diverse functions make them important players in cellular processes and potential targets for therapeutic interventions.
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Gene Regulation
Gene regulation refers to the mechanisms that control the expression of genes, determining when and how much of a gene product is made. This process is essential for maintaining cellular function and responding to environmental changes. lncRNAs can influence gene regulation by interacting with DNA, RNA, or proteins, thereby modulating the activity of specific genes.
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Review of Regulation
Epigenetics
Epigenetics involves changes in gene expression that do not alter the underlying DNA sequence but are heritable and can be influenced by environmental factors. lncRNAs are known to play a role in epigenetic regulation by recruiting chromatin-modifying complexes to specific genomic regions, thereby affecting the accessibility of DNA for transcription and influencing cellular identity and function.
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04:35Chromatin
Related Practice
Textbook Question
What are the different chromatin classifications, and what is their relationship to gene expression?
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Textbook Question
Define epigenetics, and provide examples illustrating your definition.
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Textbook Question
What are the sources of dsRNA? Diagram the mechanisms by which dsRNAs are produced and processed into small RNAs.
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Textbook Question
How does dsRNA lead to posttranscriptonal gene silencing?
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Textbook Question
A hereditary disease is inherited as an autosomal recessive trait1. The wild-type allele of the disease gene produces a mature mRNA that is 1250 nucleotides (nt) long. Molecular analysis shows that the mature mRNA consists of four exons that measure 400 nt (exon 1), 320 nt (exon 2), 230 nt (exon 3), and 300 nt (exon 4). A mother and father with two healthy children and two children with the disease have northern blot analysis performed in a medical genetics laboratory. The results of the northern blot for each family member are shown here. Identify the genotype of each family member, using the sizes of mRNAs to indicate each allele. (For example, a person who is homozygous wild type is indicated as '1250/1250.')
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