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Ch. 21 - Genomes and Their Evolution
Chapter 21, Problem 4b

(b)In the sequence for the mouse, circle any amino acid that differs from the sequence for the chimpanzee, gorilla, and rhesus monkey. Then draw a box around any amino acid that differs from the human sequence.

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Identify the amino acid sequences for the mouse, chimpanzee, gorilla, rhesus monkey, and human. Ensure that each sequence is aligned properly for accurate comparison.
Compare the mouse amino acid sequence to the sequences of the chimpanzee, gorilla, and rhesus monkey. Look for any amino acids in the mouse sequence that are different from the corresponding amino acids in these three species.
Circle the differing amino acids in the mouse sequence that you identified in the previous step. This highlights the variations between the mouse and the other non-human primates.
Next, compare the mouse amino acid sequence to the human amino acid sequence. Identify any amino acids that differ between the mouse and human sequences.
Draw a box around the differing amino acids in the mouse sequence that you identified when comparing with the human sequence. This step distinguishes the specific differences between mouse and human proteins.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Amino Acids

Amino acids are organic compounds that serve as the building blocks of proteins. Each amino acid consists of a central carbon atom, an amino group, a carboxyl group, a hydrogen atom, and a variable R group that determines its properties. The sequence of amino acids in a protein determines its structure and function, making them crucial for understanding genetic differences among species.
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Protein Sequence Alignment

Protein sequence alignment is a method used to identify similarities and differences in the amino acid sequences of proteins from different species. This technique helps in understanding evolutionary relationships and functional similarities. By comparing sequences, researchers can pinpoint specific amino acids that vary between species, which may indicate adaptations or evolutionary changes.
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Dideoxy Sequencing

Phylogenetics

Phylogenetics is the study of evolutionary relationships among biological entities, often represented in a tree-like diagram called a phylogenetic tree. By analyzing genetic sequences, scientists can infer how closely related different species are and trace their evolutionary history. This concept is essential for interpreting the significance of amino acid differences in the context of species evolution.
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Related Practice
Textbook Question

Homeotic genes a. encode transcription factors that control the expression of genes responsible for specific anatomical structures. b. are found only in Drosophila and other arthropods. c. are the only genes that contain the homeobox domain. d. encode proteins that form anatomical structures in the fly.

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Textbook Question

Two eukaryotic proteins have one domain in common but are otherwise very different. Which of the following processes is most likely to have contributed to this similarity? a. gene duplication b. alternative splicing c. exon shuffling d. random point mutations

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Textbook Question
DRAW IT Below are the amino acid sequences (using single letters; see Figure 5.14) of three short segments of the FOXP2 protein from five species. These segments contain all amino acid differences between the FOXP2 proteins of these species. Compare the amino acid sequences by answering parts (a)–(d). Chimpanzee PKSSD ... TSSTT ... NARRD Mouse PKSSE ... TSSTT ... NARRD Gorilla PKSSD ... TSSTT ... NARRD Human PKSSD ... TSSNT ... SARRD Rhesus monkey PKSSD ... TSSTT ... NARRD (a)Circle the names of any species that have identical amino acid sequences for the FOXP2 protein.
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Textbook Question

Below are the amino acid sequences (using single letters; see Figure 5.14) of three short segments of the FOXP2 protein from five species. These segments contain all amino acid differences between the FOXP2 proteins of these species. Compare the amino acid sequences by answering parts (a)–(d).


b. In the sequence for the mouse, circle any amino acid that differs from the sequence for the chimpanzee, gorilla, and rhesus monkey. Then draw a box around any amino acid that differs from the human sequence.

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Textbook Question

(d)Primates and rodents diverged about 65 million years ago, and chimpanzees and humans diverged about 6 million years ago (see Figure 21.17). How many amino acid differences are there between the sequence for the mouse and the sequence for the chimpanzee, gorilla, and rhesus monkey? How many amino acid differences are there between the human se-quence and the sequence for the chimpanzee, gorilla, and rhesus monkey? Based solely on the numbers of amino acid differences occurring over these time periods, what might you hypothesize about the rate of evolution of the FOXP2gene? Based on the information in the chapter regarding the FOXP2 gene, is your hypothesis correct?

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