Here are the essential concepts you must grasp in order to answer the question correctly.
Parathyroid Hormone (PTH)
Parathyroid hormone is a key regulator of calcium and phosphate metabolism in the body. It is secreted by the parathyroid glands and functions to increase blood calcium levels by promoting calcium release from bones, increasing intestinal absorption of calcium, and reducing renal excretion of calcium. PTH also influences phosphate levels, often leading to a decrease in serum phosphate due to increased renal excretion.
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Calcium Regulation
Calcium is essential for various physiological functions, including muscle contraction, nerve transmission, and blood coagulation. The body maintains calcium homeostasis through a balance of dietary intake, bone storage, and hormonal regulation, primarily by PTH and calcitonin. When calcium levels drop, PTH is released to restore balance, highlighting its critical role in calcium regulation.
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Phosphate Metabolism
Phosphate is vital for energy production, cellular function, and bone health. It exists in the body primarily as inorganic phosphate and is regulated by hormones such as PTH. PTH decreases phosphate reabsorption in the kidneys, leading to increased phosphate excretion, which is crucial for maintaining the proper balance of calcium and phosphate in the body.
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Introduction to Metabolism