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Ch. 26 Fluid, Electrolyte, and Acid-Base Balance
Chapter 25, Problem 6

Answer questions 5 through 10 by choosing responses from the following: a. ammonium ions b. bicarbonate c. calcium d. chloride e. hydrogen ions f. magnesium g. phosphate h. potassium i. sodium j. water Two substances regulated by parathyroid hormone.

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1
Identify the role of parathyroid hormone (PTH) in the body, which is primarily to regulate calcium levels in the blood.
Understand that PTH increases blood calcium levels by stimulating osteoclasts to break down bone and release calcium.
Recognize that PTH also influences the kidneys to reabsorb calcium and excrete phosphate, thus regulating both calcium and phosphate levels.
Consider the options provided and identify which substances are directly regulated by PTH.
Conclude that the two substances regulated by parathyroid hormone are calcium and phosphate.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Parathyroid Hormone (PTH)

Parathyroid hormone is a key regulator of calcium and phosphate metabolism in the body. It is secreted by the parathyroid glands and functions to increase blood calcium levels by promoting calcium release from bones, increasing intestinal absorption of calcium, and reducing renal excretion of calcium. PTH also influences phosphate levels, often leading to a decrease in serum phosphate due to increased renal excretion.
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Calcium Regulation

Calcium is essential for various physiological functions, including muscle contraction, nerve transmission, and blood coagulation. The body maintains calcium homeostasis through a balance of dietary intake, bone storage, and hormonal regulation, primarily by PTH and calcitonin. When calcium levels drop, PTH is released to restore balance, highlighting its critical role in calcium regulation.
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Phosphate Metabolism

Phosphate is vital for energy production, cellular function, and bone health. It exists in the body primarily as inorganic phosphate and is regulated by hormones such as PTH. PTH decreases phosphate reabsorption in the kidneys, leading to increased phosphate excretion, which is crucial for maintaining the proper balance of calcium and phosphate in the body.
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Related Practice
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Sodium balance is regulated primarily by control of amount(s) a. ingested, b. excreted in urine, c. lost in perspiration, d. lost in feces.
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Textbook Question
Water balance is regulated by control of amount(s) (use choices in question 3). a. ingested, b. excreted in urine, c. lost in perspiration, d. lost in feces.
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Textbook Question
Answer questions 5 through 10 by choosing responses from the following: a. ammonium ions b. bicarbonate c. calcium d. chloride e. hydrogen ions f. magnesium g. phosphate h. potassium i. sodium j. water Two main substances regulated by the influence of aldosterone on the kidney tubules.
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Textbook Question
Answer questions 5 through 10 by choosing responses from the following: a. ammonium ions b. bicarbonate c. calcium d. chloride e. hydrogen ions f. magnesium g. phosphate h. potassium i. sodium j. water Two substances secreted into the proximal convoluted tubules in exchange for sodium ions.
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Textbook Question
Answer questions 5 through 10 by choosing responses from the following: a. ammonium ions b. bicarbonate c. calcium d. chloride e. hydrogen ions f. magnesium g. phosphate h. potassium i. sodium j. water Part of an important chemical buffer system in plasma.
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Textbook Question
Answer questions 5 through 10 by choosing responses from the following: a. ammonium ions b. bicarbonate c. calcium d. chloride e. hydrogen ions f. magnesium g. phosphate h. potassium i. sodium j. water Two ions produced during catabolism of glutamine.
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