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Ch. 25 Fluid, Electrolyte, and Acid-Base Homeostasis

Chapter 25, Problem 25.4a

Diabetic ketoacidosis is characterized by an increased level of ketone bodies, which causes metabolic acidosis. A patient in diabetic ketoacidosis will have an altered rate of ventilation. Will the patient be hyperventilating or hypoventilating? How will a change in the rate and depth of ventilation compensate for an acidosis that is metabolic in nature?

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Hey, everyone. Let's take a look at this question. Together. In diabetic ketoacidosis, the increased level of ketone bodies leads to metabolic acidosis in response to metabolic acidosis. A patient typically experiences hyperventilation. Why does this usually happen? Is it answer choice A to conserve more carbon dioxide. Answer choice B to eliminate excess carbon dioxide. Answer choice C to conserve more oxygen or answer choice D to eliminate excess oxygen. Let's work this problem out together to try to figure out which of the following answer choices best explains why patients with metabolic acidosis typically experience hyperventilation. So in order to solve this question, we have to understand metabolic acidosis and its relationship to hyperventilation, which we can recall that metabolic acidosis results in an accumulation of carbonic acid in the blood, which we know that carbonic acid is formed by the reaction between carbon dioxide and water. Since the increased level of ketone bodies, which leads to metabolic acidosis tells us that there is an increase in the amount of carbon diet oxide in the blood. So that excess carbon dioxide joins with water to form carbonic acid as a result of that metabolic acidosis. And in terms of hyperventilation. We note that hyperventilation is an increase in the rate and the depth of breathing. Which hyperventilation is important in metabolic acidosis as that increase in the rate and depth of breathing allows for the patient to eliminate that excess carbon dioxide that is present due to metabolic acidosis and eliminating that excess carbon dioxide is important. Since eliminating the excess carbon dioxide from the body through hyperventilation, decreases the partial pressure of carbon dioxide in the blood which results in a decreased carbon acid concentration. Since we are eliminating that excess carbon dioxide, so it cannot form that carbonic acid with water resulting in that decreased carbonic acid concentration. So, in patients with diabetic ketoacidosis, which leads to metabolic acidosis, patient typically experiences hyperventilation as a way to answer choice. B eliminate excess carbon dioxide. Since hyperventilation helps allow the patient to eliminate excess carbon dioxide, preventing that formation of carbonic acid and counteracting the effects of metabolic acidosis that resulted from diabetic ketoacidosis. So, answer choice B is the only correct answer choice. I hope you found this video to be helpful. Thank you and goodbye.
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Explain how the amount of water in the body affects the concentration of ions and solutes in the ECF.

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Ms. Johanssen is a patient in the hospital. The nurse examines her laboratory reports and notices that she has developed hyperkalemia and acidosis over the past several days. On closer examination of her medical chart, the nurse also sees that her physician recently doubled her dose of spironolactone, an aldosterone-blocking diuretic. How does this explain her laboratory findings?

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Textbook Question

As a percentage of body weight, the total body water tends to be higher in ________ and lower in ________ ​.


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A laboratory printout of arterial blood gases indicates that a patient has an increased Pco₂ , decreased pH, and normal bicarbonate ion concentration. Is this patient in acidosis or alkalosis? Is the pH disturbance respiratory or metabolic in nature? Explain your reasoning. How long do you think the patient has had this pH disturbance? (Hint: Look at the bicarbonate ion concentration. What system controls the concentration of bicarbonate ions, and how quickly does it compensate for pH disturbances?)

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