22. Carboxylic Acid Derivatives: NAS
Transesterification
4:53 minutes
Problem 21.46
Textbook Question
Textbook QuestionAcid-catalyzed transesterification and Fischer esterification take place by nearly identical mechanisms. Transesterification can also take place by a base-catalyzed mechanism, but all attempts at base-catalyzed Fischer esterification (using -OR″, for example) seem doomed to failure. Explain why Fischer esterification cannot be catalyzed by base.
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