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Ch. 14+15 - Principles of Disease and Epidemiology | Microbial Mechanisms of Pathogenicity
Chapter 11, Problem 15.10a

Which of the following statements is true?
a. The primary goal of a pathogen is to kill its host.
b. Evolution selects for the most virulent pathogens.
c. A successful pathogen doesn't kill its host before it is transmitted.
d. A successful pathogen never kills its host.

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1
Understand the relationship between pathogens and their hosts. Pathogens rely on their hosts for survival and reproduction, so killing the host too quickly can be detrimental to the pathogen's ability to spread.
Consider the concept of virulence. While high virulence can lead to severe disease, it is not always advantageous for the pathogen if it results in the host's death before transmission.
Evaluate the statement that a successful pathogen doesn't kill its host before it is transmitted. This aligns with the idea that pathogens need to spread to new hosts to continue their life cycle.
Analyze the statement that a successful pathogen never kills its host. While some pathogens may not kill their hosts, others may do so after transmission has occurred, so this statement is not universally true.
Conclude that the most accurate statement is that a successful pathogen doesn't kill its host before it is transmitted, as this allows for the continuation of the pathogen's life cycle.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Pathogen-Host Relationship

The relationship between a pathogen and its host is complex and often characterized by a balance between harm and survival. While pathogens can cause disease, their primary goal is not necessarily to kill the host, as this would limit their own survival and transmission opportunities.
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Symbiotic Relationships

Virulence and Evolution

Virulence refers to the degree of damage a pathogen can cause to its host. Evolution tends to favor pathogens that can effectively exploit their hosts without killing them too quickly, as this allows for greater transmission and survival of the pathogen's lineage.
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Transmission Success

A successful pathogen is one that can spread effectively from one host to another. This often means that it must maintain the host's health long enough for transmission to occur, indicating that high virulence is not always advantageous for the pathogen's long-term success.
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Transmission Electron Microscope (TEM)
Related Practice
Textbook Question

Use the following information to answer questions 8–10.


A Maryland woman was hospitalized with dehydration. V. cholerae and Plesiomonas shigelloides were isolated from the patient, who had neither traveled outside the United States nor eaten raw shellfish during the preceding month. The patient had attended a party before hospitalization. Two other people at the party had acute diarrheal illness and elevated levels of serum antibodies against Vibrio. Everyone at the party ate crabs and rice pudding with coconut milk. Crabs left over from this party were served at a second party. One of the people at the second party had onset of mild diarrhea; specimens from of these people were negative for vibriocidal antibodies.


This is an example of

a. vehicle transmission.

b. airborne transmission.

c. transmission by fomites.

d. direct contact transmission.

e. healthcare-associated transmission.

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Textbook Question

This microbe is acquired by humans as infants and is essential for good health. Acquiring a closely related strain causes severe stomach cramps, bloody diarrhea, and vomiting. What is the microbe?

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Textbook Question

The Opa gene is used to identify this endotoxin-producing bacterium that grows well in the high- CO₂ conditions inside phagocytes.

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Textbook Question

Compare pathogenicity with virulence.

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Textbook Question

What is the LD₅₀ for the bacterial toxin tested in the following example? <IMAGE>

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Textbook Question

Which of the following is not a portal of entry for pathogens?

a. mucous membranes of the respiratory tract

b. mucous membranes of the digestive canal

c. skin

d. blood

e. parenteral route

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