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Ch. 14+15 - Principles of Disease and Epidemiology | Microbial Mechanisms of Pathogenicity
Chapter 11, Problem 14.9a

This microbe is acquired by humans as infants and is essential for good health. Acquiring a closely related strain causes severe stomach cramps, bloody diarrhea, and vomiting. What is the microbe?

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1
Identify the microbe that is commonly acquired by humans as infants and is beneficial for health.
Consider the role of gut microbiota in human health, focusing on beneficial bacteria.
Recognize that Escherichia coli (E. coli) is a common gut bacterium acquired early in life.
Differentiate between the beneficial strains of E. coli and pathogenic strains that cause gastrointestinal issues.
Conclude that the microbe in question is likely a strain of E. coli, with pathogenic strains causing severe symptoms.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Microbiota and Human Health

The human microbiota consists of trillions of microorganisms, including bacteria, that inhabit various parts of the body. These microbes play a crucial role in digestion, immune function, and overall health. A balanced microbiota is essential for preventing diseases and maintaining homeostasis, particularly in infants who acquire beneficial strains from their mothers.
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Pathogenic vs. Non-Pathogenic Strains

Microbes can be classified as pathogenic or non-pathogenic based on their effects on the host. Non-pathogenic strains contribute positively to health, while pathogenic strains can cause illness. Understanding the differences between these strains is vital, as acquiring a pathogenic strain of a closely related microbe can lead to severe gastrointestinal symptoms, such as cramps and diarrhea.
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Transmission of Microbes

Microbes are transmitted through various routes, including direct contact, ingestion, and environmental exposure. In infants, the initial acquisition of beneficial microbes often occurs during birth and breastfeeding. This early exposure is critical for establishing a healthy microbiome, which can be disrupted by the introduction of harmful strains, leading to adverse health effects.
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Related Practice
Textbook Question

Use the following information to answer questions 6–7.

On September 6, a 6-year-old boy experienced fever, chills, and vomiting. On September 7, the child was hospitalized with diarrhea and swollen lymph nodes under both arms. On September 3, he had been scratched and bitten by a cat. The cat was found dead on September 5, and Y. pestis was isolated from the cat. Chloramphenicol was administered to the child from September 7, when Y. pestis was isolated from his blood. On September 17, the child's temperature returned to normal. On September 22, the child was released from the hospital


Identify the prodromal period for this disease.

a. September 3-5

b. September 3-6

c. September 6-7

d. September 6-17

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Textbook Question

Put the following in the correct order to describe the pattern of disease: period of convalescence, prodromal period, period of decline, incubation period, period of illness.

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Textbook Question

Use the following information to answer questions 8–10.


A Maryland woman was hospitalized with dehydration. V. cholerae and Plesiomonas shigelloides were isolated from the patient, who had neither traveled outside the United States nor eaten raw shellfish during the preceding month. The patient had attended a party before hospitalization. Two other people at the party had acute diarrheal illness and elevated levels of serum antibodies against Vibrio. Everyone at the party ate crabs and rice pudding with coconut milk. Crabs left over from this party were served at a second party. One of the people at the second party had onset of mild diarrhea; specimens from of these people were negative for vibriocidal antibodies.


This is an example of

a. vehicle transmission.

b. airborne transmission.

c. transmission by fomites.

d. direct contact transmission.

e. healthcare-associated transmission.

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Textbook Question

The Opa gene is used to identify this endotoxin-producing bacterium that grows well in the high- CO₂ conditions inside phagocytes.

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Textbook Question

Which of the following statements is true?

a. The primary goal of a pathogen is to kill its host.

b. Evolution selects for the most virulent pathogens.

c. A successful pathogen doesn't kill its host before it is transmitted.

d. A successful pathogen never kills its host.

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Textbook Question

Compare pathogenicity with virulence.

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