What is the LD₅₀ for the bacterial toxin tested in the following example?

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Hi, everyone. Welcome back. Our next problem says LD subscript 50 is tested to check which of the following a measure the short term poisoning, potential or acute toxicity of a material B measuring how much of a chemical is required to cause death. C determine the lethal dose or concentration of a substance that causes death in 50 per cent of the test population or d all of the above. So let's work through our answers and think about them remembering that we do have the option of more than one correct answer. So LD 50 by strict definition is choice C it determines the lethal dose or concentration of a substance that causes death in 50% of the test population. So choice C is a correct definition but we know we have the potential for more than one correct answer. So just put a little dot there rather than selecting it. And there's some general ranges that come along with it in general. If it takes a dose of less than 500 mg per kilogram to cause death in 50% of the test population, that would be considered high toxicity. Where is the value of 500 to 1000 mg per kilogram is moderate toxicity and a value of 1500 to 2000 mg per kilogram to reach this death and 50% level is low toxicity. So just to give you a feel for what those values are, so let's look at our other answer. Choices to see is this our only answer or are others correct as well? Choice. A measure the short term poison poisoning potential or the acute toxicity of a material. Well, this is also correct because it's not looking at, if we administer this dose over time, does it build up and eventually cause death? No, it's a single dose of the tested material. So it's the acute toxicity or short term potential. What is the result of just a single dose? So we already have more than one correct answer. So we know our answer will be choice D all of the above, but just to be thorough, let's look at choice B it says measuring how much of a chemical is required to cause a death. And yes, this is the correct description. Now, granted we have this 50% figure, but this gives you an idea of how much in general and at least half the time is required to cause death, which would give you a good shot at estimating how much is required to cause death, say 99.9% of the time. So once again, LD subscript 50 is measured, tested to check which of the following and the answer is choice D all of the above see you in the next video.

What is the LD₅₀ for the bacterial toxin tested in the following example? <IMAGE>

Verified Solution

Key Concepts

LD₅₀

Bacterial Toxins

Dose-Response Relationship