Mutations in tumor-suppressor genes are associated with many types of cancers. In addition, epigenetic changes (such as DNA methylation) of tumor-suppressor genes are also associated with tumorigenesis [Otani et al. (2013). Expert Rev Mol Diagn 13:445–455].

How might hypermethylation of the TP53 gene promoter influence tumorigenesis?

Video transcript

Hello everyone and welcome to today's video. So the silencing of the gene caused by hyper methylation of the TP 53 gene promoter can result in which of the following consequences. Well, remember that methylation is a process that can either enhance or repress gene expression here. In the question we're saying that is silencing the gene expression of this T P 53 gene. Now, what is this going to result in before we jump into that? Let's remember that the TP 53 gene is a two more suppressor. So if it is repressed or if it is silent, it's two more suppressed. Your ability is going to be compromised. Well, knowing that let's jump over into our answer choices beginning by answer choice. The loss of its tumor suppressor function. Again, if its size system or suppressor function will definitely be compromised. This is a correct answer choice. So we're not going to cancel this out and increased risk of tumor genesis. While these two more genesis refers to the creation or the formation of tumors. If a tumor suppressor is affected, then the formation of tumors may be more observed. It may be more common because of this. It is actually a correct answer choices. But also we're not going to cancel it out. Then we have sea uncontrolled cell proliferation and the formation of tumors. This is more or less the same as answer choice B And it is a consequence as well of the silencing of this gene. So we're not going to cancel this out. And then we have the all of the above. Since we're not able to cancel out any of the answer choices, we're going to select answer choice. All of the above are correct. I really hope this video helped you, and I hope to see you on the next one.