Mutations in tumor-suppressor genes are associated with many types of cancers. In addition, epigenetic changes (such as DNA methylation) of tumor-suppressor genes are also associated with tumorigenesis [Otani et al. (2013). Expert Rev Mol Diagn 13:445–455].

Knowing that tumors release free DNA into certain surrounding body fluids through necrosis and apoptosis Kloten et al. [(2013). Breast Cancer Res. 15(1):R4] outline an experimental protocol for using human blood as a biomarker for cancer and as a method for monitoring the progression of cancer in an individual.

Video transcript

Everyone. Let's take a look at this question together. At what stage of lung cancer development is the blood cell count most likely to get affected? Let's recall what we know about the different stages of lung cancer. To try to figure out at what stage does the blood cell count get affected. So we know that when lung cancer has metastasized, meaning it spreads to other places in the body, so it spreads two other Justin organs or tissues. This means that we have increased levels of lymphocyte as well as neutrophils and lately and this is due to infection. And so this is the point where that blood cell count is most likely to get affected when lung cancer has metastasized and this occurs in stage or of lung cancer. So that would make answer choice B. The correct answer. Because in Stage four of lung cancer development, that is when lung cancer has metastasized, meaning that it spreads to other parts of the body And we have those increased levels of those lymphocytes, neutrophils and platelets due to that infection and that is when that blood cell count is most likely to get affected in stage four. So, answer choice B is the correct answer. I hope you found this video to be helpful. Thank you and goodbye