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Ch. 23 - Developmental Genetics

Chapter 22, Problem 12

The homeotic mutation Antennapedia causes mutant Drosophila to have legs in place of antennae and is a dominant gain-of-function mutation. What are the properties of such mutations? How does the Antennapedia gene change antennae into legs?

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Hey, everyone. Let's take a look at this question together. How does a mutation in the antenna PD A gene affect the body? So let's recall what the purpose of the antenna PD A gene is. And if it was mutated, how it would affect the body. Well, we note that the antenna PD A gene is the gene that is responsible responsible for the development of specific body parts in organisms which include the antennae and the legs. And we know that the antenna PD A gene is a homo box jean which regulate the expression of other genes within the organism. And these other genes are those that control development. And so when we have that mutation in this gene, the mutation can alter the expression of jeans that control leg development, which can lead to the development of extra legs. So that means that answer choice. A is the correct answer because this antenna PD A gene which is the gene that is responsible for the development of specific body parts in an organism, which include the antenna and the legs. And it is a homo box gene which regulates the expression of other genes, which means that a mutation in that gene can alter the expression of genes that control leg development leading to extra legs. So answer choice A is the correct answer. I hope you found this video to be helpful. Thank you and goodbye.
Related Practice
Textbook Question
Experiments have shown that any nuclei placed in the polar cytoplasm at the posterior pole of the Drosophila egg will differentiate into germ cells. If polar cytoplasm is transplanted into the anterior end of the egg just after fertilization, what will happen to nuclei that migrate into this cytoplasm at the anterior pole?
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Textbook Question
How can you determine whether a particular gene is being transcribed in different cell types?
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Textbook Question

You observe that a particular gene is being transcribed during development. How can you tell whether the expression of this gene is under transcriptional or translational control?

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Textbook Question

The Drosophila homeotic mutation spineless aristapedia (ssᵃ) results in the formation of a miniature tarsal structure (normally part of the leg) on the end of the antenna. What insight is provided by (ssᵃ) concerning the role of genes during determination?

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Textbook Question

Embryogenesis and oncogenesis (generation of cancer) share a number of features including cell proliferation, apoptosis, cell migration and invasion, formation of new blood vessels, and differential gene activity. Embryonic cells are relatively undifferentiated, and cancer cells appear to be undifferentiated or dedifferentiated. Homeotic gene expression directs early development, and mutant expression leads to loss of the differentiated state or an alternative cell identity. M. T. Lewis [(2000). Breast Can. Res. 2:158–169] suggested that breast cancer may be caused by the altered expression of homeotic genes. When he examined 11 such genes in cancers, 8 were underexpressed while 3 were overexpressed compared with controls. Given what you know about homeotic genes, could they be involved in oncogenesis?

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Textbook Question

The specification of the anterior–posterior axis in Drosophila embryos is initially controlled by various gene products that are synthesized and stored in the mature egg following oogenesis. Mutations in these genes result in abnormalities of the axis during embryogenesis. These mutations illustrate maternal effect. How do such mutations vary from those produced by organelle heredity? Devise a set of parallel crosses and expected outcomes involving mutant genes that contrast maternal effect and organelle heredity.

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