Skip to main content
Ch. 21 - Genomic Analysis

Chapter 20, Problem 22

Homology can be defined as the presence of common structures because of shared ancestry. Homology can involve genes, proteins, or anatomical structures. As a result of 'descent with modification,' many homologous structures have adapted different purposes. Under what circumstances might one expect proteins of similar function to not share homology? Would you expect such proteins to be homologous at the level of DNA sequences?

Verified Solution
Video duration:
3m
This video solution was recommended by our tutors as helpful for the problem above.
212
views
Was this helpful?

Video transcript

Welcome back. Let's look at our next problem. The pax six gene carries genetic the genetic information that encodes the pax six protein which controls i development and other sensory organs. The pax six from other vertebrates and Drosophila. Eyeless gene share similar sequences and functions. This can indicate. And we see that we've got choice, a analogy choice be ornithology, choice C. Pathology or choice D. Zen ology. Well, we know we have here genes from very divergent species and yet they still share similar sequences and functions and that's despite their divergence from each other. So we look at our answer choices. Choice B. Ornithology. Orthe ologists. Ornithologist genes are homologous genes that are still similar despite a speciation event. So those similarities are due to descent from a single gene in the last common ancestor. So despite these 22 species growing apart becoming very different they still have this shared gene from a common ancestor. So let's look at our other answer choices to understand why they're not correct. Choice a analogy. Well, analogous structures are where you have similarity in function not do to a common ancestor. So instead of that similarity and function and sometimes inform being due to descent from a common ancestor in analogy you have that similarity due to similar environments. Similar evolutionary pressures to create that structure. So that's why that's not correct. Oh I see. Para ology is when genes you have homologous genes due to um gene duplication. So it's in a single organism. You had a gene duplication event. And now you have two homologous genes within that same organism. So not the example of genes that were still similar despite a speciation event, That's why that's not correct. And then finally Choice D. Is enology. And in that case you have homologous genes again. But that's due to horizontal gene transfer from another species. So not due to descent from a common ancestor but due to a gene being transferred from an over from another species. So that's why that's not correct. So again with we had the pax six gene um necessary for eye development and the pax six gene invertebrates and the shuffles eyeless gene share similar sequences and functions. This can indicate choice B or theology. See you in the next video.
Related Practice
Textbook Question
Researchers have compared candidate loci in humans and rats in search of loci in the human genome that are likely to contribute to the constellation of factors leading to hypertension [Stoll, M., et al. (2000). Genome Res. 10:473–482]. Through this research, they identified 26 chromosomal regions that they consider likely to contain hypertension genes. How can comparative genomics aid in the identification of genes responsible for such a complex human disease? The researchers state that comparisons of rat and human candidate loci to those in the mouse may help validate their studies. Why might this be so?
254
views
Textbook Question
Homology can be defined as the presence of common structures because of shared ancestry. Homology can involve genes, proteins, or anatomical structures. As a result of 'descent with modification,' many homologous structures have adapted different purposes. List three anatomical structures in vertebrates that are homologous but have different functions.
360
views
Textbook Question
Homology can be defined as the presence of common structures because of shared ancestry. Homology can involve genes, proteins, or anatomical structures. As a result of 'descent with modification,' many homologous structures have adapted different purposes. Is it likely that homologous proteins from different species have the same or similar functions? Explain.
297
views
Textbook Question

Yeager, M., et al. [(2007) Nature Genetics 39:645–649] and Sladek, R., et al. [(2007) Nature 445:881–885] have used single-nucleotide polymorphisms (SNPs) in genome-wide association studies (GWAS) to identify novel risk loci for prostate cancer and Type 2 diabetes, respectively. Each study suggests that disease-risk genes can be identified that significantly contribute to the disease state. Given your understanding of such complex diseases, what would you determine as reasonable factors to consider when interpreting the results of GWAS?

231
views
Textbook Question
Comparisons between human and chimpanzee genomes indicate that a gene that may function as a wild-type or normal gene in one primate may function as a disease-causing gene in another [The Chimpanzee Sequencing and Analysis Consortium (2005). Nature 437:69–87]. For instance, the PPARG locus (regulator of adipocyte differentiation) is a wild-type allele in chimps but is clearly associated with Type 2 diabetes in humans. What factors might cause this apparent contradiction? Would you consider such apparent contradictions to be rare or common? What impact might such findings have on the use of comparative genomics to identify and design therapies for disease-causing genes in humans?
444
views
Textbook Question

Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development.

What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer.

213
views